STARTING OXLUMO™(lumasiran)

Dosing for OXLUMO

Doses of OXLUMO are based on how much you weigh. While taking OXLUMO, 3 starting doses will be given monthly to help bring urinary oxalate levels down. After the 3 starting doses, ongoing doses will be given to help keep urinary oxalate levels down.

Dosing with OXLUMO happens in 2 phases

STARTING DOSES

Three doses are given 1 month apart at the start of treatment to help bring urinary oxalate levels down.

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ONGOING DOSES

Ongoing dosing begins 1 month after the last starting dose to help keep urinary oxalate levels down.

Dose frequency is based on body weight:

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1 dose per 3 months

For patients weighing 10 kg (22 lb) or more

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1 dose per month

For children under 10 kg (22 lb)

Your doctor is your primary source of information regarding dosing for OXLUMO.
You can also refer to the Prescribing Information to learn more.

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If a dose is delayed or missed, contact your doctor as soon as possible. 

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How OXLUMO is given

OXLUMO is an injection administered by a healthcare provider. 

  • Injections are given under the skin
  • Injection sites can include the abdomen, thighs, or upper arms
  • OXLUMO can cause injection site reactions. Symptoms included redness, pain, itching, or swelling at the site of injection
  • Doses are usually given in a doctor’s office, though some patients may qualify for in-home nursing support, depending on their insurance coverage
  • In a 6-month clinical trial of 39 adults and children (age 6 and up), the most common side effect reported was injection site reaction. Injection site reactions occurred throughout the study period and symptoms included redness, pain, itching, or swelling at the site of injection

Want to know more about in-home nursing?

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IMPORTANT SAFETY INFORMATION

The most common side effect of OXLUMO™ (lumasiran) is injection site reaction (redness, pain, itching, and swelling at the site of injection). These are not all the possible side effects of OXLUMO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

OXLUMO has not been studied in pregnant or breastfeeding women. Talk to your doctor about the risk of taking OXLUMO if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

WHAT IS OXLUMO?

OXLUMO is a prescription medicine for the treatment of primary hyperoxaluria type 1 (PH1) to lower oxalate in urine in children and adults.  

For additional information about OXLUMO, please see full Prescribing Information.