WHAT IS PH1?

Understanding primary hyperoxaluria type 1 (PH1)

PH1 is a genetic disease that is rare and progressive. If you have PH1, it is important to work with your doctor.

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PH1 causes the body to produce too much oxalate

  • Oxalate is a waste product that is mostly removed by the kidneys
  • In PH1, too much oxalate is made in the body
  • As excess oxalate moves through the kidneys, it can form crystals that may cause kidney stones

How PH1 can affect the body

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Kidney stones are the most common symptom of PH1 Any kidney stone in a child or adolescent or recurring stones in adults can be signs of PH1.

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PH1 is more than a kidney stone disease Even if someone is not experiencing kidney stones, too much oxalate can cause serious damage to their kidneys and other organs.

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Too much oxalate in the body can lead to permanent damage PH1 can result in kidney failure that may require dialysis and potentially lead to a kidney transplantation. That’s why PH1 may require ongoing management and monitoring with your doctor and a well-coordinated care team.

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PH1 can affect each person differently It is important to work closely with your doctor to develop a personalized management plan.

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CONNECT WITH AN EDUCATOR

Learn about PH1 and treatment with OXLUMOTM from a trained patient educator.

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Support and resources are available throughout your treatment journey

Find support that can help you and your family during treatment with OXLUMO.

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IMPORTANT SAFETY INFORMATION

The most common side effect of OXLUMO™ (lumasiran) is injection site reaction (redness, pain, itching, and swelling at the site of injection). These are not all the possible side effects of OXLUMO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

OXLUMO has not been studied in pregnant or breastfeeding women. Talk to your doctor about the risk of taking OXLUMO if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

WHAT IS OXLUMO?

OXLUMO is a prescription medicine for the treatment of primary hyperoxaluria type 1 (PH1) to lower oxalate in urine in children and adults.  

For additional information about OXLUMO, please see full Prescribing Information.